Isolation of Sterol-resistant Chinese Hamster Ovary Cells with Genetic Deficiencies in Both Insig-1 and Insig-2
Open Access
- 1 July 2005
- journal article
- Published by Elsevier
- Vol. 280 (26) , 25242-25249
- https://doi.org/10.1074/jbc.m502989200
Abstract
No abstract availableKeywords
This publication has 28 references indexed in Scilit:
- Insig-dependent Ubiquitination and Degradation of Mammalian 3-Hydroxy-3-methylglutaryl-CoA Reductase Stimulated by Sterols and GeranylgeraniolJournal of Biological Chemistry, 2003
- Accelerated Degradation of HMG CoA Reductase Mediated by Binding of Insig-1 to Its Sterol-Sensing DomainMolecular Cell, 2003
- Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteinsProceedings of the National Academy of Sciences, 2002
- Crucial Step in Cholesterol HomeostasisCell, 2002
- The sterol-sensing domain: multiple families, a unique role?Trends in Genetics, 2002
- SREBPs: Transcriptional Mediators of Lipid HomeostasisCold Spring Harbor Symposia on Quantitative Biology, 2002
- A proteolytic pathway that controls the cholesterol content of membranes, cells, and bloodProceedings of the National Academy of Sciences, 1999
- Topology of SREBP Cleavage-activating Protein, a Polytopic Membrane Protein with a Sterol-sensing DomainJournal of Biological Chemistry, 1998
- Immunological evidence for eight spans in the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme A reductase: implications for enzyme degradation in the endoplasmic reticulumThe Journal of cell biology, 1992
- Regulation of the mevalonate pathwayNature, 1990