An Evaluation of the Role of Ferritin (VDM) in Traumatic Shock.

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Abstract
150-200-g. male Wistar rats were subjected to trauma in the Noble-Collip Drum for 405 revolutions. 68 rats had high ferritin concns. in their livers produced by intraperit. Hb injn. (3 mg. Fe). 80 untreated rats served as controls. Mortality rates were 77.9% and 70% and mean death times were 1.87 hrs. and 2.03 hrs., respectively. Statistical considerations of these data indicate no significant difference between the groups. 46 untreated rats drummed at 450 revolutions received 0.5 ml. of high titer antiserum to dog ferritin immediately post-drumming. This antiserum was shown to recover 99% rat ferritin in vitro and to persist in the rat circulation at least 24 hrs. when recipient rat serum was tested with rat ferritin. 43 rats, receiving 0.5 ml. of normal rabbit serum and the same trauma served as controls. Mortality rates of 79.1% and 76.1% and mean death times of 1.44 hrs. and 1.39 hrs., respectively,were without significant differences. It is concluded that increased ferritin in tissues or its removal from the circulation by antibody neutralization is without effect on outcome of traumatic shock. This contradicts the theory that ferritin (VDM) has a causal role in shock.