17. Purification and Aggregation of Influenza Virus by Precipitation with Polyethylene Glycol
- 1 January 1993
- journal article
- research article
- Published by Taylor & Francis in Preparative Biochemistry
- Vol. 23 (1-2) , 207-225
- https://doi.org/10.1080/10826069308544551
Abstract
Influenza virus may be purified and rendered free of extraneous proteins by precipitation and aggregation with polyethylene glycol at polymer concentrations of 1 to 4%. The precipitated virus is superior antigenically to the virus in monomeric and in the ether dissociated forms. When the virus is precipitated at polyethylene glycol concentrations of 5% and higher the virus is not aggregated and is associated with extraneous protein which co-precipitates with the infectious agent.Keywords
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