Genome-wide scan linkage analysis for Parkinson's disease: the European genetic study of Parkinson's disease
Open Access
- 1 December 2004
- journal article
- research article
- Published by BMJ in Journal of Medical Genetics
- Vol. 41 (12) , 900-907
- https://doi.org/10.1136/jmg.2004.022632
Abstract
Objective: To undertake a full genome-wide screen for Parkinson’s disease susceptibility loci. Methods: A genome-wide linkage study was undertaken in 227 affected sibling pairs from 199 pedigrees with Parkinson’s disease. The pedigree sample consisted of 188 pedigrees from five European countries, and 11 from the USA. Individuals were genotyped for 391 microsatellite markers at ∼10 cM intervals throughout the genome. Multipoint model-free affected sibling pair linkage analyses were carried out using the MLS (maximum LOD score) test. Results: There were six chromosomal regions with maximum MLS peaks of 1 or greater (pointwise pConclusions: These stratified linkage analyses suggest linkage heterogeneity within the sample across the 2p11–q12 and 5q23 regions, with these two regions contributing independently to Parkinson’s disease susceptibility.Keywords
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