TRAUMATIC SHOCK. XIV. THE SUCCESSFUL TREATMENT OF HEMORRHAGIC SHOCK BY VIVI-PERFUSION OF THE LIVER IN DOGS IRREVERSIBLE TO TRANSFUSION 1

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Abstract
Eight of the 9 dogs in hemorrhagic shock irreversible to transfusion recovered after perfusion of the liver by cross-circulation via the splenic vein with a healthy donor dog. Seven of 9 dogs similarly treated, except that the donor''s blood entered the femoral instead of the splenic vein, did not survive. These observations demonstrate (1) that liver damage is intimately related to the collapse of the peripheral vascular mechanism in advanced hemorrhagic shock, (2) that restoration of the integrity of the liver is necessary for recovery of function of the peripheral vascular system in advanced hemorrhagic shock, and (3) that restoration of this aspect of liver function can be accomplished by providing adequate bJood flow from a donor dog to the liver, even after "irreversibility" to transfusion has been demonstrated.