Thermal Tolerance and Repair of Thermal Damage by Cultured Cells
- 1 May 1977
- journal article
- research article
- Published by Radiological Society of North America (RSNA) in Radiology
- Vol. 123 (2) , 505-509
- https://doi.org/10.1148/123.2.505
Abstract
Exposure of hamster cells to 42.5.degree. C for long periods leads to the development of thermal tolerance. The slope of the survival curve becomes shallower after .apprx. 3.5-4 h. If two 4 h exposures at 42.5.degree. C are separated by various periods of time, thermal tolerance is eliminated by 20 h. Prolonged exposure at 42.5.degree. C offers considerable protection from subsequent treatments to acute hyperthermia at 45.degree. C. Split exposures at 45.degree. C indicate a repair mechanism similar to that of X-rays. Posttreatment maintenance for 5 h at 4.degree. C or in conditioned medium or balanced salt solution failed to reveal any evidence of repair of potentially lethal damage. [This study is a model for cancer treatment.].This publication has 4 references indexed in Scilit:
- Cellular Responses to Combinations of Hyperthermia and RadiationRadiology, 1977
- Interaction of Hyperthermia and Radiation in CHO Cells: Recovery KineticsRadiation Research, 1976
- The Effect of Hyperthermia on the Repair of Radiation Damage in Plateau Phase CellsRadiology, 1976
- Repair of Potentially Lethal Damage in X-Irradiated HeLa CellsRadiation Research, 1966