THE INDUCTION OF LIVER TYROSINE 2-OXOGLUTARATE TRANSAMINASE IN RATS BY IMMOBILIZATION

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Abstract
The immobilization of unfasted young female rats caused a linear increase in liver tyrosine 2-oxoglutarate transaminase activity reaching a four fold level within 12 hours. This was followed by a decrease. No gastric lesions were observed macroscopically in 26 hours, but in many cases these appeared after immobilization of at least 40 hours. The enzyme activity in the liver of rats with macroscopic gastric lesions was double or more than double the activity in immobilized rats with no lesions or in non-immobilized control animals. The increase was partially inhibited by pretreating the animals 30 minutes before immobilization with a subcutaneous injection of actinomycin D. Adrenalectomized rats showed no increase in enzyme activity during immobilization.