Control of ammonium ion level for efficient nanaomycin production.
- 1 January 1984
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 37 (11) , 1370-1375
- https://doi.org/10.7164/antibiotics.37.1370
Abstract
The addition of a small amount of NH4+ to a complex medium increased nanaomycin production by Streptomyces rosa ssp. notoensis OS-3966. The best NH4+ donor for nanaomycin production was NH4+-saturated natural zeolite, with which the maximum titer of nanaomycin E was 760 .mu.g/ml, about 4-fold higher than the control titer. Lowering NH4+ levels by adding NH4+-trapping agents such as untreated natural zeolite reduced antibiotic [antibacterial and antifungal drug] production.This publication has 6 references indexed in Scilit:
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