Testosterone Metabolism in Various Tissues of the Intact and Inflamed Rabbit Eye
- 1 January 1976
- journal article
- research article
- Published by S. Karger AG in Ophthalmic Research
- Vol. 8 (5) , 374-378
- https://doi.org/10.1159/000264845
Abstract
[4–14C]-testosterone in rabbit cornea, iris, retina and lens is metabolised in vitro by specific steroid oxidoreductases. The main product was 4-androstene-3,17-dione followed by 5α-dihydrotestosterone, androstanediols, androstanedione, epitestosterone and androsterone. The metabolic activity of vitreous was very low and practically no metabolism occurred in aqueous. Inflammation due to Escherichia coli endotoxin significantly decreased testosterone metabolism in cornea and iris.Keywords
This publication has 1 reference indexed in Scilit:
- Identification and radioimmunologic estimation of sexual steroid hormones in aqueous humor and vitreous of rabbit eyeAlbrecht von Graefes Archiv für Ophthalmologie, 1976