Substituted Xanthones as Selective and Reversible Monoamine Oxidase A (MAO-A) Inhibitors
- 1 January 1993
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 10 (8) , 1187-1190
- https://doi.org/10.1023/a:1018924503552
Abstract
L,3-Dihydroxy-2-methylxanthone (XI), its 4-chloro and 4-bromo derivatives (X1-C1 and Xl-Br), and 1 ,3-dihydroxy-4-methylxanthone were investigated for their inhibition activities toward MAO. A hyperbolic function was derived to fit the data and to calculate IC50 values. The compounds proved to be reversible and selective inhibitors of MAO-A, with XI displaying the highest activity (IC50 = 3.7 µM).Keywords
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