Tissue-specific transcriptional regulation has diverged significantly between human and mouse
Top Cited Papers
- 21 May 2007
- journal article
- research article
- Published by Springer Nature in Nature Genetics
- Vol. 39 (6) , 730-732
- https://doi.org/10.1038/ng2047
Abstract
We demonstrate that the binding sites for highly conserved transcription factors vary extensively between human and mouse. We mapped the binding of four tissue-specific transcription factors (FOXA2, HNF1A, HNF4A and HNF6) to 4,000 orthologous gene pairs in hepatocytes purified from human and mouse livers. Despite the conserved function of these factors, from 41% to 89% of their binding events seem to be species specific. When the same protein binds the promoters of orthologous genes, approximately two-thirds of the binding sites do not align.Keywords
This publication has 15 references indexed in Scilit:
- Large-Scale Turnover of Functional Transcription Factor Binding Sites in DrosophilaPLoS Computational Biology, 2006
- GENE EXPRESSION IN HUMAN HEPATOCYTES IN SUSPENSION AFTER ISOLATION IS SIMILAR TO THE LIVER OF ORIGIN, IS NOT AFFECTED BY HEPATOCYTE COLD STORAGE AND CRYOPRESERVATION, BUT IS STRONGLY CHANGED AFTER HEPATOCYTE PLATINGDrug Metabolism and Disposition, 2006
- The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cellsNature Genetics, 2006
- Core transcriptional regulatory circuitry in human hepatocytesMolecular Systems Biology, 2006
- A hypothesis-based approach for identifying the binding specificity of regulatory proteins from chromatin immunoprecipitation dataBioinformatics, 2005
- Core Transcriptional Regulatory Circuitry in Human Embryonic Stem CellsCell, 2005
- Identification of a Locus for Maturity-Onset Diabetes of the Young on Chromosome 8p23Diabetes, 2004
- Regulatory phases of early liver development: paradigms of organogenesisNature Reviews Genetics, 2002
- Use of human hepatoma cells for in vitro metabolic activation of chemical mutagens/carcinogensMutagenesis, 1991
- Evolution at Two Levels in Humans and ChimpanzeesScience, 1975