Decreased Antithrombin III Activity in Diabetes May Be Due to Non-Enzymatic Glycosylation – A Preliminary Report
- 1 January 1983
- journal article
- research article
- Published by Georg Thieme Verlag KG in Thrombosis and Haemostasis
- Vol. 50 (03) , 633-634
- https://doi.org/10.1055/s-0038-1665274
Abstract
Antithrombin III activity was moderately but significantly decreased in insulin dependent diabetics (p <0.005), while no difference has been found between the diabetic (n = 25) and control groups (n = 22) in antithrombin III plasma concentration. Moreover, antithrombin III activity was inversely correlated with glycosylated plasma proteins (r = -0.57; p <0.01). These data show that in diabetes there is a depressed biological activity of antithrombin III and suggest that this reflects nonenzymatic glycosylation of antithrombin III protein.Keywords
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