FACTORS AFFECTING THE SURVIVAL OF THE ADRENAL MEDULLA AND ASSOCIATED CORTICAL CELLS IN THE ANTERIOR CHAMBER OF THE RABBIT'S EYE

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Abstract
SUMMARY: Pieces of adrenal medulla, together with inner zone cortical cells, were inserted into the anterior chamber of the rabbit's eye in eighty-four instances. Care was taken to exclude the outer parts of the adrenal cortex. Both chromaffin and cortical cells were vascularized by the iris and persisted in the eye for many months in spite of the presence of the whole or part of the right adrenal gland. Partial removal of the right adrenal gland was followed by a proliferation of the cortical elements of the graft. ACTH injections (5 mg twice daily for 21 days) did not induce cellular proliferation. The findings indicate that adrenocortical cells will persist in a graft and proliferate in spite of the presence of abdominal adrenocortical tissue and that the inner zone cells of the rabbit's adrenal can be successfully grafted and are capable of proliferating in response to a partial removal of the remaining normal adrenal cortex.