ON THE UPTAKE OF NYSTATIN BY SACCHAROMYCES-CEREVISIAE .2. EFFECTS OF PH, IONIC-STRENGTH, STEROL CONCENTRATION AND PROTECTING IONS
- 1 January 1981
- journal article
- research article
- Vol. 31 (123) , 7-16
Abstract
Uptake of nystatin by sensitive cells of S. cerevisiae was studied as a function of pH and ionic strength. The pH was shown to affect radically uptake kinetics and extent, while ionic strength variation appeared not to modify uptake at all. The effects of variation in the sterol concentration of the cells employed showed a decrease in nystatin uptake as sterol concentration increased. This was not the anticipated observation. Ca ions were shown to protect the yeast cells by associating with the cell and not the antibiotic. Possible explanations are discussed.This publication has 12 references indexed in Scilit:
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