Trioxacarcins, novel antitumor antibiotics. II. Isolation, physico-chemical properties and mode of action.
- 1 January 1981
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 34 (12) , 1525-1530
- https://doi.org/10.7164/antibiotics.34.1525
Abstract
Novel antitumor antibiotics, trioxacarcin complex, were isolated from the fermentation broth of Streptomyces bottropensis DO-45 by the use of non-ionic porous resin and silica gel chromatography. The purified components (trioxacarcins A, B and C) were characterized as new antibiotics by their physico-chemical properties and chromatographic behaviors. The mode of action of trioxacarcin A against Bacillus subtilis was through the inhibition of DNA synthesis.This publication has 2 references indexed in Scilit:
- Trioxacarcins, novel antitumor antibiotics. I. Producing organism, fermentation and biological activities.The Journal of Antibiotics, 1981
- Tetrocarcins, novel antitumor antibiotics. II. Isolation, characterization and antitumor activity.The Journal of Antibiotics, 1980