Trioxacarcins, novel antitumor antibiotics. I. Producing organism, fermentation and biological activities.

Abstract
A group of antitumor antibiotics with a novel skeleton, trioxacarcins, was discovered in culture broths of actinomycete strain DO-45. The producing organism was subsequently determined to be a new strain and named Streptomyces bottropensis sp. nov. The antibiotics are active against gram-positive bacteria and experimental murine tumors such as sarcoma 180 and leukemia P388.