Modelling neurodegenerative diseases in Drosophila: a fruitful approach?
- 1 March 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Neuroscience
- Vol. 3 (3) , 237-243
- https://doi.org/10.1038/nrn751
Abstract
Human neurodegenerative diseases are characterized by the progressive loss of specific neuronal populations, resulting in substantial disability and early death. The identification of causative single-gene mutations in families with inherited neurodegenerative disorders has facilitated the modelling of these diseases in experimental organisms, including the fruitfly Drosophila melanogaster. Many neurodegenerative diseases have now been successfully modelled in Drosophila, and genetic analysis is under way in each of these models. Using fruitfly genetics to define the molecular pathways that underlie the neurodegenerative process is likely to improve substantially our understanding of the pathogenesis of the human diseases, and to provide new therapeutic targets.Keywords
This publication has 55 references indexed in Scilit:
- Tauopathy in Drosophila : Neurodegeneration Without Neurofibrillary TanglesScience, 2001
- The Genome Sequence of Drosophila melanogasterScience, 2000
- A Drosophila model of Parkinson's diseaseNature, 2000
- Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17Nature, 1998
- AlaSOPro mutation in the gene encoding α-synuclein in Parkinson's diseaseNature Genetics, 1998
- α-Synuclein in Lewy bodiesNature, 1997
- Mutation in the α-Synuclein Gene Identified in Families with Parkinson's DiseaseScience, 1997
- Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's diseaseNeurology, 1992
- The origin of pattern and polarity in the Drosophila embryoCell, 1992
- The physical basis of heredityPublished by Biodiversity Heritage Library ,1919