A Drosophila model of Parkinson's disease
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- 1 March 2000
- journal article
- letter
- Published by Springer Nature in Nature
- Vol. 404 (6776) , 394-398
- https://doi.org/10.1038/35006074
Abstract
Parkinson's disease is a common neurodegenerative syndrome characterized by loss of dopaminergic neurons in the substantia nigra, formation of filamentous intraneuronal inclusions (Lewy bodies) and an extrapyramidal movement disorder. Mutations in the α-synuclein gene are linked to familial Parkinson's disease1,2 and α-synuclein accumulates in Lewy bodies and Lewy neurites3,4,5. Here we express normal and mutant forms of α-synuclein in Drosophila and produce adult-onset loss of dopaminergic neurons, filamentous intraneuronal inclusions containing α-synuclein and locomotor dysfunction. Our Drosophila model thus recapitulates the essential features of the human disorder, and makes possible a powerful genetic approach to Parkinson's disease.Keywords
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