Interaction of the pBR 322-coded RTEM α-lactamase with substrates. Evidence for specific conformational transitions.
- 1 February 1982
- journal article
- research article
- Published by Portland Press Ltd. in Biochemical Journal
- Vol. 201 (2) , 425-427
- https://doi.org/10.1042/bj2010425
Abstract
The rate of inactivation of RTEM-1 beta-lactamase by Pronase is accelerated by class A (‘resistant’) penicillins. Other substrates (class S penicillin and cephalosporins) protect against the inactivation. Cefoxitin, a semi-synthetic cephamycin, induces a more extensive, hysteretic response. In its presence the enzyme is inactivated by trypsin as well as by Pronase.This publication has 18 references indexed in Scilit:
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