Inhibition of dopadecarboxylase in the rat by a series of benzyloxyamines
- 1 May 1972
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 24 (5) , 361-366
- https://doi.org/10.1111/j.2042-7158.1972.tb09008.x
Abstract
A series of eleven benzyloxyamines has been evaluated for in vitro and in vivo inhibition of dopa decarboxylase. The effect of these inhibitors on the rise in [14C]amines in the brain after [14C]dopa has also been assessed. Of these compounds, 3,4-dihydroxybenzyloxyamine appears to be a potent selective peripheral inhibitor of dopa decarboxylase. Its activity is similar to that of Ro 4–4602 [N1-(dl-seryl)-N2-(2,3,4-trihydroxybenzyl) hydrazine].Keywords
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