ISOLATION, PURIFICATION, AND CHARACTERIZATION OF γ-LIPOTROPIC HORMONE FROM SHEEP PITUITARY GLANDS
- 30 June 1967
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 45 (7) , 1163-1174
- https://doi.org/10.1139/o67-133
Abstract
The isolation and characterization of a new biologically active polypeptide from sheep pituitary glands is described. Considerable evidence suggests that the structure of the new molecule, designated γ-lipotropin, is identical with the N-terminal portion (sequence 1–58) of β-lipotropin and, therefore, that γ-lipotropin contains at its C-terminus the amino acid sequence of β-melanophore-stirnulating hormone (β-MSH). The implications of these results are discussed in relation to the mechanism of pituitary peptide biosynthesis and to the structure–activity relationships between sheep β-MSH and lipotropic hormones.This publication has 20 references indexed in Scilit:
- DISC ELECTROPHORESIS – II METHOD AND APPLICATION TO HUMAN SERUM PROTEINS*Annals of the New York Academy of Sciences, 1964
- Adrenocorticotropin XXVII. On the presence of pig-tyre adrenocorticotropin in sheep pituitaries, and a simple method for the isolation of αs-adrenocorticotropinBiochimica et Biophysica Acta, 1963
- Some aspects of the relationship between chemical structure and melanocyte-stimulating properties of several peptides related to adrenocorticotropinBiochimica et Biophysica Acta, 1962
- Disk Electrophoresis of Basic Proteins and Peptides on Polyacrylamide GelsNature, 1962
- Isolation of - and -Melanocyte Stimulating Hormones (MSH) on a Preparative Scale.Experimental Biology and Medicine, 1960
- Lipolytic Action of Corticotropin on Rat Adipose Tissue In Vitro12Journal of Clinical Investigation, 1958
- IN VITRO BIOASSAY OF CORTICOTROPIN: MODIFICATION AND STATISTICAL TREATMENTEndocrinology, 1955
- Two-Dimensional Chromatography of Amino Acids on Buffered PapersAnalytical Chemistry, 1953
- Ultraviolet Absorption Spectra of Proteins and Amino AcidsAdvances in Protein Chemistry, 1952
- The pigmentary effector system. VI. The dual character of endocrine co-ordination in amphibian colour changeProceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 1931