The Fate of Circulating Osteoblasts

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Abstract
Bone remodeling is a temporally regulated process resulting in the coordinated resorption and formation of skeletal tissue carried out in basic multicellular units throughout life.1 Signals determining the fate, function, and ultimate death of cells of the osteoclast and osteoblast lineages define the populations of cells that resorb and form bone in basic multicellular units. There, osteoblasts appear at sites vacated by osteoclasts, a process called coupling. As resorption by osteoclasts is terminated, the resorptive surface is covered by a thin layer of cement, where osteoblasts assemble to form bone and fill the cavity.2 During growth, two types of bone . . .