Lipid Metabolism in X-Irradiated Mice and Rats

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Abstract
X-irradiated male Sherman strain rats and DBA/2 Jax mice (500-r and 425-r total-body dose, respectively) showed significant changes in the specific activities of total nonsaponifiable lipids, cholesterol (digitonide-precip-itated), and fatty acids (total body lipids). The latter were elevated by day 6, but by day 9 to 15 (mice and rats, respectively) these had returned to control levels. The specific activities of the cholesterol were less variable, but they were significantly low on day 9 in the mice and day 15 in the rats. Cholesterol and fatty acid metabolism were quite different, and in the latter the metabolism of the solid and liquid fatty acids were quantitatively different.