Assembly of Alzheimer‐like filaments from full‐length tau protein
- 10 January 1994
- journal article
- Published by Wiley in FEBS Letters
- Vol. 337 (2) , 135-138
- https://doi.org/10.1016/0014-5793(94)80260-2
Abstract
The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule‐associated protein tau. Here we show that recombinant tau protein either in a non‐phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease.Keywords
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