Immunologic Enhancement of Tumor Xenografts by Pepsin-Degraded Immunoglobulin

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Abstract
The serums from guinea pigs previously injected with mouse Ehrlich ascites tumor cells were fractionated to obtain γ2-immunoglobulin. This immunoglobulin was degraded with pepsin to obtain an F(ab')2 fragment. Fresh tumor cells were incubated with immunoglobulin or the fragment and injected into normal guinea pigs. The growth of these cells as tumor xenografts was inhibited by the γ2-immunoglobulin and enhanced by the F(ab')2 fragment. Similar incubation of tumor cells with normal guinea pig γ2-globulin or its derived F(ab')2 fragment did not alter subsequent tumor growth.