Functional interleukin 2 receptors on B cells lacking Tac antigens

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Abstract
Human B lymphoblastoid line, SKW 6‐4, cells were induced to IgM‐secreting cells by high concentrations of interleukin 2 (IL2). These cells were found to be unreactive with anti‐Tac antibody and did not express mRNA detectable for Tac antigen. In Scatchard plot analysis, low‐affinity IL 2‐binding sites were found on SKW 6‐4 cells. Moreover, analysis of the IL2‐binding molecules revealed ones (molecular weight 70000 and 75000) distinct from Tac antigen. It is conceivable that IL2 exerts its effect through its interaction with these novel IL2‐binding molecules in SKW 6‐4 cells.