Glucose tolerance curves in genetically diabetic KK-CAy mice: The pharmacokinetic analysis for humping effect.

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Abstract
Pharmacokinetic analysis on glucose tolerance curves in genetically diabetic KK-CAy mice treated with hypoglycemics [beef insulin, tolbutamide and phentolamine] was investigated using an analog computer. The glucose tolerance curves in KK-CAy mice showed humping phenomenon. They could not be simulated by a simple compartmental model, but might be fitted to the model containing the non-linear function. Compartment-H model was contrived by adding the H-factor between glucose and insulin compartments. All the glucose tolerance curves in the KK-CAy mice could be simulated reasonably by this model and some suggestions on the humping effect were obtained from the analysis of H-factor. The H-factor was influenced by an adrenergic .alpha.-blocker [phentolamine]. This pharmacokinetic approach may be useful for the pharmacological research.