Isolation of an Anti-inflammatory Principle from the Fruit Juice of Ecballium elaterium
- 1 May 1988
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 51 (3) , 504-508
- https://doi.org/10.1021/np50057a008
Abstract
The fruit juice of Echallium elaterium, used as a folk medicine in Turkey for the treatment of sinusitis, was investigated for its anti-inflammatory activity in mice. Fractions obtained from the juice were tested in mice for their effects on increased vascular permeability, as induced by HOAc ip. The active principle was isolated from the CHCl3 extract as well as the H2O-insoluble part of the fruit juice and identified as cucurbitacin B. This is the first report that cucurbitacin B has a significant anti-inflammatory activity.This publication has 2 references indexed in Scilit:
- Isolation and structures of arvenins from Anagallis arvensis L. (Primulaceae). New cucurbitacin glucosides.CHEMICAL & PHARMACEUTICAL BULLETIN, 1978
- THE USE OF CHANGES IN CAPILLARY PERMEABILITY IN MICE TO DISTINGUISH BETWEEN NARCOTIC AND NONNARCOTIC ANALGESICSBritish Journal of Pharmacology and Chemotherapy, 1964