PEPSIN SECRETION AND ENTEROGASTRONE

Abstract
The effect of pepsin secretion of enterogastrone concentrates prepared from hog intestinal mucosa and of endogenous enterogastrone elicited by fat in the intestine was studied in dogs with vagally innervated and vagally denervated pouches of the stomach. The total output of pepsin in response to histamine or piloearpine stimulation is moderately depressed by endogenous and exogenous enterogastrone. Depression of pepsin conc, after fat adm. occurs only in the vagally innervated pouch. Therefore vagal nervous influences are extensively concerned in the inhibition by fat of pepsin secretion.

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