Febrile Response Following Intravenous Administration of Fat

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Abstract
Fat emulsions prepared from pyrogen-free materials in pyrogen-free equipment and immediately sterilized produce a thermogenic effect in rabbits when tested by the U.S.P. pyrogen test. Treatment of the oils and the emulsions by known methods of destroying bacterial pyrogens, such as the use of H2O2, Darco, acid, etc., does not eliminate this fever reaction. Both crude and highly purified fats produce thermogenic emulsions. Emulsions immediately prepared with rabbit fat that has been sterilely collected from freshly killed animals are thermogenic. Incorporation of 2% Triton A-20 into the emulsions eliminates this fever reaction and also inhibits the rate at which injd. fat disappears from the blood. It is concluded that the thermogenic response caused by the intraven. injn. of fat emulsion is an inherent effect.
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