Intravenous Infusions of a Combined Fat Emulsion into Human Subjects.

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Abstract
A sterile 10% combined fat emulsion for intraven. infusion into humans, consisting of 10% fatty oil (coconut oil), 5% protein hydrolysate, 5% glucose and 2% gelatin as the emulsifying agent, with a caloric value of about 1300 cal./l., pH about 6.2 and particle size less than 1 [mu], is prepared in a specially constructed homo-genizer so that its working parts in contact with the sterile ingredients may be assembled as a sterile unit. The 10% combined fat emulsion was infused intraven. into 76 human subjects for a total of more than 250 1., with an avg. of 4 1. of emulsion administered to each of 35 patients, 1 receiving a total of 16 1. There was a low incidence of reactions, temp. rises ranged from none to very mild increases with 8% rising more than 3[degree]F. Chills occurred in 9% of 200 studies and vomiting in only 2%. There were no hemolytic reactions, no liver damage as indicated by surgical biopsies and functions tests during infusion study periods and follow-up studies weeks later. Chest X-Ray studies revealed no lesions attributable to fat embolization. Chylomicron studies of blood coincided with chemical nephelometric, viscosimetric and refractometric detns., indicating a rapid removal of fat from the circulating blood. The clinical observations and controlled studies with a variety of laboratory tests provided evidence in favor of its suitability as an intraven. fat emulsion for admn. to humans.
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