The effect of obstructive jaundice on the migration of reticulo-endothelial cells and fibroblasts into early experimental granulomata

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Abstract
Clinical and experimental evidence indicates that obstructive jaundice inhibits the healing of wounds. Experiments in the rat designed to investigate the migration of reticulo-endothelial and fibroblasts into experimental granulomata are described. Standard preparations of obstructive jaundice and controls were devised using Wistar rats. The effects of bile-duct obstruction and sham ligation are described. In another group of animals which was similarly prepared granuloma-pouch experiments were carried out by burying sterile cotton-wool pledgets of a known weight. These peledgets were removed from the jaundiced and control animals on the third, fifth, seventh, and ninth days after implantation, dried to remove the fluid component of the inflammatory process, and weighed on a microbalance. The weights were compared and it was found that a significant inhibition of weight increase occurred in the jaundiced animals during the first week, suggesting a delay in the migratory activity of reticuloendothelial cells and fibroblasts.

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