The mechanism of anaphylaxis: specificity of antigen-induced mast cell damage in anaphylaxis in the guinea pig.

  • 1 January 1959
    • journal article
    • Vol. 2  (1) , 31-43
Abstract
Mast cell damage, characterized by loss of granules, occurs when the tissues of sensitized guinea pigs are brought into contact with antigen in vivo or in vitro. Quantitative studies on the mesenteries of passively sensitized guinea pigs show that the mast cell response to antigen is well correlated with the development of anaphylactic shock. After multiple sensitization contact with different antigens caused cumulative, but not complete, disappearance of mast cells.