A New Class of 5-Fluoro-2?-deoxyuridine Prodrugs Conjugated with a Tumor-Homing Cyclic Peptide CNGRC by Ester Linkers: Synthesis, Reactivity, and Tumor-Cell?Selective Cytotoxicity
- 21 March 2005
- journal article
- research article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 22 (3) , 381-389
- https://doi.org/10.1007/s11095-004-1875-x
Abstract
Tumor-targeting prodrugs of 5-fluoro-2′-deoxyuridine (5-FdUrd), which are chemical conjugations of 5-FdUrd with a tumor-homing cyclic peptide CNGRC by succinate and glutarate linkers, were synthesized to investigate the structural effects of linkers on the hydrolytic release of 5-FdUrd and the tumor-cell–selective cytotoxicity.Keywords
This publication has 37 references indexed in Scilit:
- Molecular targeting of angiogenesisBiochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2004
- Immunotherapy of Malignant DiseasesInternational Archives of Allergy and Immunology, 2003
- Combinatorial discovery of tumor targeting peptides using phage displayJournal of Cellular Biochemistry, 2003
- Nanoparticles in cancer therapy and diagnosisAdvanced Drug Delivery Reviews, 2002
- Specialization of tumour vasculatureNature Reviews Cancer, 2002
- An Address System in the Vasculature of Normal Tissues and TumorsAnnual Review of Immunology, 2000
- A photoactivated prodrugBioorganic & Medicinal Chemistry Letters, 1998
- Convenient one-pot synthesis of cystine-containing peptides using the trimethylsilyl chloride–dimethyl sulfoxide/trifluoroacetic acid system and its application to the synthesis of bifunctional anti-HIV compounds 1Journal of the Chemical Society, Perkin Transactions 1, 1998
- Organ targeting In vivo using phage display peptide librariesNature, 1996
- In vitro antitumor activity of 2'-deoxy-5-fluorouridine-monoclonal antibody conjugatesBioconjugate Chemistry, 1991