Further Observations on Effect on Plasma 17-OH-Corticosteroids in the Dog of Derivatives of 2,2-Bis-(p-Chlorophenyl)-1,1-Dichloroethane (DDD, TDE).

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Abstract
The effect of 8 derivatives of 2,2-bis-(p-chlorophenyl)-l,l-dichloroethane (DDT, TDE) on the responsiveness of the adrenal cortex to ACTH, as determined by changes in plasma 17-hydroxycorticoids, has been studied in dogs. The following derivatives decreased the corticoid response: those with para-phenyl modifications; bromine substitution of the aliphatic chlorines; hydroxylation on the 2-position of the ethane moiety. No change in response was noted with a derivative in which hydrogen replaced chlorine in the 1-position of the ethane moiety, and with benzophenone, a possible DDD metabolite. Somewhat equivocal results were obtained with an ethylene analogue.