EFFECT OF HEPARIN ON PLASMA LIPID PARTITION IN MAN: STUDIES IN NORMAL PERSONS AND IN PATIENTS WITH CORONARY ATHEROSCLEROSIS, NEPHROSIS AND PRIMARY HYPERLIPEMIA

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Abstract
A comparison was made of the effect of intraven. injd. heparin on plasma lipid partition and plasma clearing in 10 normal men, 5 patients with coronary atherosclerosis, 7 patients in the nephrotic state of nephritis, and 3 with idiopathic hyperlipemia. Blood samples drawn before heparin admn. and 15, 60, and 120 min. later indicated an appreciable reduction in plasma total lipids, primarily in neutral fat content. Plasma cholesterol, esterified cholesterol, and phospholipid fractions were unaffected. As measured by light transmission, plasma opacity or turbidity was reduced after heparin injn. in all groups, but to a variable degree. Plasma of normal subjects, and especially that of normal men with induced alimentary lipemia, cleared to a greater extent than plasma of patients in the other 3 categories. Fasting plasma of patients with nephrosis and essential hyperlipemia, usually opaque before heparin injn., cleared least of all. In the nephrotic group an increase in dosage of heparin did not affect plasma lactescence. Light transmission of plasma was associated only in a general way with its lipid content. In patients with nephrosis and essential hyperlipemia, plasma clearing induced by heparin seemed unrelated to the observed fall in neutral fat.