DIURETIC AND URICOSURIC ACTIVITY OF 6,7-DICHLORO-2,3-DIHYDRO-5-(2-THIENYLCARBONYL)BENZOFURAN-2-CARBOXYLIC ACID AND STEREOISOMERS IN CHIMPANZEE, DOG AND RAT
- 1 January 1980
- journal article
- research article
- Vol. 212 (2) , 190-197
Abstract
The racemate and the d-isomer of 6,7-dichloro-2,3-dihydro-5-(2-thienylcarbonyl)benzofuran-2-carboxylic acid exhibited diuretic activity in the chimpanzee, dog and rat. In the chimpanzee, the diuresis and natriuresis are presumably due to a site of action in the thick ascending limb of Henle''s loop. The l-isomer was uricosuric but devoid of any diuretic action in the chimpanzee and was not diuretic in the dog and rat. Various proportions of the 2 isomers were tested in the chimpanzee in an attempt to produce an optimal diuretic and uricosuric profile. Apparently the racemic mixture, under these experimental conditions, was responsible for the most effective overall response. This is apparently the 1st time there is a distinct separation of diuretic and uricosuric actions in the enantiomers of a racemic diuretic uricosuric agent.This publication has 7 references indexed in Scilit:
- RENAL EXCRETION OF A SALURETIC-URICOSURIC AGENT (MK-196) AND INTERACTION WITH A URATE-RETAINING DRUG, PYRAZINOATE, IN CHIMPANZEE1977
- SALURETIC AND URICOSURIC EFFECTS OF (6,7-DICHLORO-2-METHYL-1-OXO-2-PHENYL-5-INDANYLOXY)ACETIC ACID (MK-196) IN CHIMPANZEE1977
- Hypoglycemic and uricosuric properties of acetohexamide and hydroxyhexamideMetabolism, 1968
- POTASSIUM-SPARING AND NATRIURETIC ACTIVITY OF N-AMIDINO-3,5-DIAMINO-6-CHLOROPYRAZINECAR-BOXAMIDE HYDROCHLORIDE DIHYDRATE (AMILORIDE HYDROCHLORIDE)1967
- RENOTROPIC CHARACTERISTICS OF ETHACRYNIC ACID - A PHENOXYACETIC SALURETIC-DIURETIC AGENT1965
- DIURETIC AND NATRURETIC ACTIVITY OF TRIAMTERENE AND SEVERAL RELATED PTERIDINES IN RAT1965
- MUTUAL SUPPRESSION OF THE URICOSURIC EFFECTS OF SULFINPYRAZONE AND SALICYLATE: A STUDY IN INTERACTIONS BETWEEN DRUGS*Journal of Clinical Investigation, 1963