MUTUAL SUPPRESSION OF THE URICOSURIC EFFECTS OF SULFINPYRAZONE AND SALICYLATE: A STUDY IN INTERACTIONS BETWEEN DRUGS*

Open Access
Publisher Website
Google Scholar
Abstract
In man, the uricosuria produced by sulfinpyrazone is suppressed by uricosuric doses of salicylate, and the uricosuria produced by salicylate is likewise suppressed by sulfinpyrazone. In the dog, this antagonism between drugs is not demonstrable, nor could a paradoxical response to salicylate, like that in man, be elicited. Two sites of interaction between sulfinpyrazone and salicylate were demonstrated, competition for binding sites on plasma proteins and competition for renal tubular transport. In both man and dog, sulfinpyrazone was displaced from binding sites on plasma proteins by salicylate in the concentrations employed. In man, sulfinpyrazone appears to compete successfully with salicylate for tubular secretion, but salicylate apparently blocks the inhibitory effect of sulfinpyrazone on tubular reabsorption of uric acid.