A Facile Synthesis of (2R3S)-1-Amino-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutane;A Useful Component Block of HIV Protease Inhibitor
- 1 February 1998
- journal article
- research article
- Published by Taylor & Francis in Synthetic Communications
- Vol. 28 (3) , 395-401
- https://doi.org/10.1080/00397919808005092
Abstract
(S)-3-tert-Butoxycarbonylamino-1-nitro-2-oxo-4-phenylbutan 4 was converted to (2R, 3S)-1-amino-3-tert-butoxycarbonylamino-2-hydroxy-4-phenylbutane 5a by a catalytic hydrogenation, or NaBH4-TiCl4 reduction followed by hydrogenation in favorable diastereoselectivity, a component of the HIV protease inhibitor VX-478.Keywords
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