Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures
- 1 July 1988
- journal article
- research article
- Published by Springer Nature in Neurochemical Research
- Vol. 13 (7) , 605-610
- https://doi.org/10.1007/bf00973275
Abstract
Several aspects of energy metabolism (glucose utilization, lactate production,14CO2 production from labeled glucose, glutamate or pyruvate, oxygen consumption and contents of ATP and phosphocreatine) were measured in cerebellar granule cells (glutamatergic) in primary cultures and compared with corresponding data for cerebral cortical neurons (mainly GABA-ergic) and astrocytes. Cerebellar granule cells and astrocytes were metabolically more active than cerebral cortical neurons. Glutamate which is utilized as a major metabolic fuel as astrocytes and, to a lesser extent, in cerebral cortical neurons, was virtually not oxidized in cerebellar granule cells.Keywords
This publication has 34 references indexed in Scilit:
- Adenosine metabolism in neurons and astrocytes in primary culturesJournal of Neuroscience Research, 1989
- Effects of Ammonia and β‐Methylene‐dl‐Aspartate on the Oxidation of Glucose and Pyruvate by Neurons and Astrocytes in Primary CultureJournal of Neurochemistry, 1988
- Glial glutamate dehydrogenase: Ultrastructural localization and regional distribution in relation to the mitochondrial enzyme, cytochrome oxidaseJournal of Neuroscience Research, 1987
- Effects of barbiturates on energy metabolism by cultured astrocytes and neurons in the presence of normal and elevated concentrations of potassiumNeuropharmacology, 1986
- Substrate utilization for energy production and lipid synthesis in oligodendrocyte-enriched cultures prepared from rat brainNeurochemistry International, 1986
- Glutamine Oxidation by Dissociated Cells and Homogenates of Rat Brain: Kinetics and Inhibitor StudiesJournal of Neurochemistry, 1984
- Respiration in Primary Cultured Cerebellar Granule Neurons and Cerebral Cortical NeuronsJournal of Neurochemistry, 1984
- Influence of Pathological Concentrations of Ammonia on Metabolic Fate of 14C‐Labeled Glutamate in Astrocytes in Primary CulturesJournal of Neurochemistry, 1984
- Regulation of Glycogen Metabolism in Primary and Transformed Astrocytes In VitroJournal of Neurochemistry, 1983
- Survival and maturation of cerebral neurons on poly(l-lysine) surfaces in the absence of serumDevelopmental Biology, 1980