COMPARISON OF EFFECTS OF 6-THIO-PURINE RIBONUCLEOSIDE CYCLIC MONOPHOSPHATES AND 6-METHYLTHIOPURINE RIBONUCLEOSIDE CYCLIC MONOPHOSPHATES WITH THEIR CORRESPONDING NUCLEOSIDES ON GROWTH OF RAT HEPATOMA-CELLS

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 37  (3) , 651-657
Abstract
The cyclic nucleotide forms of 6-mercaptopurine and 6-methylmercaptopurine were cytotoxic to rat hepatoma cells. Studies with an inhibitor of phosphodiesterase suggest that the cytotoxicity of both cyclic nucleotides results from conversion to the 5''-nucleotide. A comparison of the 2 thiopurine cyclic nucleotides with their nucleoside counterparts suggested that the thio derivatives act by a common mechanism which is different from that exerted by the methylthio derivatives, and the methylthio cyclic nucleotide acts, at least in part, by a mechanism which differs from that exerted by the methylthio nucleoside.