Engineered Biosynthesis of Antiprotealide and Other Unnatural Salinosporamide Proteasome Inhibitors
- 31 May 2008
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 130 (25) , 7822-7823
- https://doi.org/10.1021/ja8029398
Abstract
A new shunt in the phenylalanine biosynthetic pathway to the nonproteinogenic amino acid l-3-cyclohex-2′-enylalanine was exploited in the marine bacterium Salinispora tropica by mutagenesis to allow for the genetic engineering of unnatural derivatives of the potent proteasome inhibitor salinosporamide A (2) such as antiprotealide (1).Keywords
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