Insulin-Regulatory Mechanisms and Diabetes Mellitus

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Abstract
STUDIES have shown that the administration of sodium tolbutamide results in a rise of the insulin content of the pancreatic venous blood of laboratory animals1 2 3 4 5 and also in the peripheral venous blood of nondiabetic human subjects and patients with non iabetes.2 , 6 These findings confirm Loubatières's7 suggestion that the sulfonylureas stimulate the pancreas and exert their action through the release of endogenous insulin.The studies reported here provide evidence that tolbutamide has at least a dual action: it stimulates the release of insulin from the pancreas and also increases the rate of utilization of the inactive form of circulating insulin both . . .