THE EFFECT OF OESTROGEN AND ANTI-OESTROGENS ON OVUM TRANSPORT IN MICE

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Abstract
Summary. Oestradiol-17β, dimethylstilboestrol (dms), MER-25 and MRL-37 given on Days 1 to 3 of pregnancy caused retention of ova in the oviduct. None of the compounds increased the numbers of overtly abnormal ova although they all increased the proportion of morulae to blastocysts found on Day 4. This apparent delay in development was not observed when ova were retained by ligation. Although it seems likely that the anti-oestrogens were effective by virtue of their oestrogenic properties they did not reduce the numbers of ova recovered, whereas oestradiol-17β did. The mechanism whereby ova are lost is not clear.