Anti‐inflammatory and immunomodulatory activities of polysaccharide from Chlorella stigmatophora and Phaeodactylum tricornutum
- 16 June 2003
- journal article
- research article
- Published by Wiley in Phytotherapy Research
- Vol. 17 (6) , 665-670
- https://doi.org/10.1002/ptr.1227
Abstract
Crude polysaccharide extracts were obtained from aqueous extracts of the microalgae Chlorella stigmatophora and Phaeodactylum tricornutum. The crude extracts were fractionated by ion-exchange chromatography on DEAE-cellulose columns. The molecular weights of the polysaccharides in each fraction were estimated by gel filtration on Sephacryl columns. The crude polysaccharide extracts of both microalgae showed anti-inflammatory activity in the carrageenan-induced paw edema test. In assays of effects on the delayed hyper-sensitivity response, and on phagocytic activity assayed in vivo and in vitro, the C. stigmatophora extract showed immunosuppressant effects, while the P. tricornutum extract showed immunostimulatory effects. Copyright © 2003 John Wiley & Sons, Ltd.Keywords
This publication has 13 references indexed in Scilit:
- Antiinflammatory, analgesic and free radical scavenging activities of the marine microalgaeChlorella stigmatophora andPhaeodactylum tricornutumPhytotherapy Research, 2001
- Effects ofChlorella stigmatophoraExtract on the Central Nervous SystemPlanta Medica, 1993
- Effects ofSkeletonema costatumExtracts on the Central Nervous SystemPlanta Medica, 1992
- Effects ofPhaeodactylum tricornutum and Dunaliella tertiolectaExtracts on the Central Nervous SystemPlanta Medica, 1990
- Stress and Immune Responses III. Effect of Restraint Stress on Delayed Type Hypersensitivity (DTH) Response, Natural Killer (NK) Activity and Phagocytosis in MiceThe Japanese Journal of Pharmacology, 1986
- Carbohydrates of the brown seaweeds himanthalia lorea, bifurcaria bifurcata, and Padina pavoniaCarbohydrate Research, 1973
- 1298. The carbohydrates of phaeodactylum tricornutum. Part I. Preliminary examination of the organism, and characterisation of low molecular weight material and of a glucanJournal of the Chemical Society, 1965
- 1299. Carbohydrates of Phaeodactylum tricornutum. Part II. A sulphated glucuronomannanJournal of the Chemical Society, 1965
- Determination of inorganic sulphate in studies on the enzymic and non-enzymic hydrolysis of carbohydrate and other sulphate estersBiochemical Journal, 1961
- Colorimetric Method for Determination of Sugars and Related SubstancesAnalytical Chemistry, 1956