SOME ENDOCRINE FACTORS IN THE POLYURIC ACTION OF RENIN1

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Abstract
DIFFERENT authors have shown that the injection of renin produces polyuria in rabbits (Pickering, 1940; Brandt et al., 1948; Hughes, et al., 1949); and in rats (Addis et al., 1949; Masson et at., 1950; Sellers et al., 1951; Croxatto et al., 1951). The polyuric effect of renin is abolished by adrenalectomy in rats maintained on 1% NaCl drinking solution (Croxatto et al., 1952). The different behavior of renin in normal and adrenalectomized rats is observed both in animals normally hydrated with free intake of water and in water-loaded animals. Whether the adrenal factor involved in the action of renin arose from the cortex or medulla and whether or not it involved interaction with either the anterior or posterior pituitaries are questions left unanswered by past work. The present experiments were designed to provide such answers. materials and methods Pig renin was prepared according to the method of Braun Menendez (1943).

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