Biochemical Tests for the Appraisal of Exposure to Lead

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Abstract
Increases in the rate of the excretion of δ-aminoievulinic acid and, to a slightly lesser extent, increase in the excretion of coproporphyrin, in the urine of persons subjected to occupational exposure to lead, parallel the increase in the excretion of lead in the urine (and the concentration of lead in the blood). Data derived from a study of groups of workmen subjected to varying degrees of exposure have been assembled to demonstrate the gradation of these several responses to graduated occupational exposure to lead, and to provide collective criteria for the establishment of threshold limits.