Isoniazid Prophylaxis Re-Examined
- 16 September 1971
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 285 (12) , 687-689
- https://doi.org/10.1056/nejm197109162851212
Abstract
New developments in the chemotherapy of tuberculosis have thrown present policies and practices regarding isoniazid (INH) chemoprophylaxis into question. The eradication of tuberculosis by the systematic treatment of tuberculin reactors with INH was proposed during the 1950's. After experimental studies had rendered encouraging results in 1959, Lambert1 questioned the role of INH as a chemoprophylactic agent. He asked, "How effective is INH in preventing tuberculous disease? What are the risks of drug toxicity in large populations treated with INH?"The efficacy of INH chemoprophylactic management of tuberculin reactors was well established in large, well controlled and triple-blind studies* conducted by . . .Keywords
This publication has 4 references indexed in Scilit:
- Chemoprophylaxis of Tuberculosis: When Is the Benefit Worth the Risk and Cost?Annals of Internal Medicine, 1971
- False Elevations of Serum Glutamic-Oxalacetic Transaminase Due to Para-Aminosalicylic AcidAnnals of Internal Medicine, 1970
- Hepatitis after Isoniazid AdministrationNew England Journal of Medicine, 1970
- The Chemoprophylaxis of Tuberculosis1American Review of Respiratory Disease, 1959