ENDOCRINE FACTORS INFLUENCING TUMOR DEVELOPMENT ADMINISTRATION OF GONADOTROPINS AT THE EARLY CANCER AGE TO MARSH-BUFFALO MICE1

Publisher Website
Google Scholar
Abstract
In virgin [female] mice of the Marsh-Buffalo strain, the adm. of 100 Cole-Saunders units of pregnant mare serum hormone per mouse, initiated at the age of 7 mos. (the early cancer age) and repeated through a 3-mo. period, produced marked ovarian stimulation with marked alveolar development of the breast, but failed to alter appreciably the course of appearance of tumors of the mammary gland. Adm. of 12 mg. per mouse of sheep pituitary gonadotrophic hormone at the same age and over the same period produced marked ovarian stimulation with marked alveolar development of the mammary gland after the first series of injs., followed by a 2-mo. period of induced atrophy of the ovaries and mammary glands. The course of the development of tumors of the mammary gland was not appreciably altered.