Nouvelles Voies D'Accès Aux Acides Cinnamiques. Application à la Synthèse des Acides O‐Méthylthio et O‐Méthylsélénocinnamiques Simples et Substitués

Publisher Website
Google Scholar
Abstract
1‐thio‐ and 1‐seleno‐coumarins are synthesized by cyclization of o‐methylthio and o‐methylselenocinnamic acids. The Reformatsky reaction provides a route to cinnamic acids from o‐methylthio and o‐methylselenobenzaldehydes, acetophenones and benzophenones but ethyl bromacetate behaves abnormally owing to SCH3 or SeCH3; a solution is found by preparing first the organozincic. The Perkin synthesis is also used for benzaldehydes. New methods were investigated from acetophenones and benzophenones: condensation of ethyl cyanacetate and malononitrile with benzylamine as catalyst and condensation with acetonitrile or ethyl acetate and LiNH2. Application is given for several o‐methylthio and o‐methylselenocinnamic acids.

This publication has 15 references indexed in Scilit: